By C. Parsloe (auth.), Prof. Antonino Gullo M.D. (eds.)
The curiosity of researchers, clinicians, practitioners and surgeons in serious care drugs is becoming. scientific pharmacology and new applied sciences now let extra acceptable cures, and the dedication of all these desirous about this box is of primary significance for attaining excessive interventional criteria, in either the prevention and therapy of severe stipulations, but in addition for enjoyable the idea that of cost-effectiveness in serious care. during this quantity advances in severe care drugs are defined, together with the appliance of recent applied sciences within the medical atmosphere, the whole integration of desktops and informatics, and the continuous education of physicians and technicians.
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Extra resources for Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.: Proceedings of the 15th Postgraduate Course in Critical Care Medicine Trieste, Italy — November 17–21, 2000
P. NOVELLI The microcirculation (MC) is the terminal region of the circulatory system that is fundamental in the pathophysiology of sepsis and septic shock. As is well known, its main components are arterioles, venules, shunts, and mostly capillaries. All the structures in the MC are capable of contraction, except capillaries which are made of endothelial cells alone, without contractile structures, except those (named "precapillary sphincters") placed at the beginning of the vessels. However, capillaries might undergo changes of local hemodynamics during sepsis due to active constriction of sphincters, mechanical or cellular obstruction, endothelial or interstitial edema.
34] pointed out that the different hemodynamic responses observed during several hemodilution techniques are due to the great variability of protocols and mostly due to of the anesthetic regimen employed. These authors did not observe any increase in cardiac index in ASA I patients anesthetized with enflurane and fentanyl. Rosberg and Wulff  in elderly patients anesthetized with droperidol, fentanyl, and nitrous oxide had the same results, which were also verified by Van Der Linden et al. .
Van Woerkens ECSM, Trouwborst A, Lanschot JJB (1992) Profound hemodiluiton: what is the critical level of hemodilution at which oxygen delivery-dependent oxygen consumption starts in an anaesthetised human? Anesth Analg 75:818-821 26. Trouwborst A, van Bommel J, Ince C eta! (1998) Monitoring normovolemic haemodilution. Br J Anesth 8l[Suppl]:73-78 27. Baron JF, De Kegel D, Prost ACeta! (1991) Low molecular weight hydroxyethyl starch 6% compared to albumin 4% during intentional hemodilution. Intensive Care Med 17:141-148 28.
Anaesthesia, Pain, Intensive Care and Emergency Medicine — A.P.I.C.E.: Proceedings of the 15th Postgraduate Course in Critical Care Medicine Trieste, Italy — November 17–21, 2000 by C. Parsloe (auth.), Prof. Antonino Gullo M.D. (eds.)