Read e-book online Antibacterial Agents: Chemistry, Mode of Action, Mechanisms PDF

By Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley

ISBN-10: 0470972440

ISBN-13: 9780470972441

Antibacterial brokers act opposed to bacterial an infection both via killing the bacterium or by way of arresting its progress. They do that by way of concentrating on bacterial DNA and its linked tactics, attacking bacterial metabolic techniques together with protein synthesis, or interfering with bacterial telephone wall synthesis and function.

Antibacterial Agents is an important advisor to this crucial type of chemotherapeutic medicines. Compounds are organised in keeping with their objective, which is helping the reader comprehend the mechanism of motion of those medicinal drugs and the way resistance can come up. The publication makes use of an built-in “lab-to-clinic” technique which covers drug discovery, resource or synthesis, mode of motion, mechanisms of resistance, scientific points (including hyperlinks to present instructions, major drug interactions, cautions and contraindications), prodrugs and destiny improvements.

Agents coated include:

  • agents focusing on DNA - quinolone, rifamycin, and nitroimidazole antibacterial agents
  • agents concentrating on metabolic techniques -  sulfonamide antibacterial brokers and trimethoprim
  • agents concentrating on protein synthesis - aminoglycoside, macrolide and tetracycline antibiotics, chloramphenicol, and oxazolidinones
  • agents concentrating on cellphone wall synthesis - β-Lactam and glycopeptide antibiotics, cycloserine, isonaizid, and daptomycin

Antibacterial Agents will discover a position at the bookshelves of scholars of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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Extra info for Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Example text

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Pharmaceutical companies must make a profit to continue to be viable and so target chronic diseases, aiming for blockbuster drugs which will be given to patients for lengthy periods, in order to maximise their return on the massive costs associated with drug discovery and the short period during patent protection in which they, and they alone, can make a profit from the sale of a particular drug. Narrow-spectrum antibacterial agents, which will be used for the treatment of acute illnesses, and which are at risk of quickly becoming obsolete as a result of the emergence of bacterial resistance, are not commercially attractive to pharmaceutical companies.

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Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications by Rosaleen Anderson, Paul Groundwater, Adam Todd, Alan Worsley


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